Calorie Restriction the CR Way is a stem cell diet

The concept of how we age is changing. It is now known that every organ has its own pool of stem cells. Like an old car, that “runs out of gas” permanently, our organs run out of stem cells, fall into disrepair, and eventually die.

However, there is hope – for unlike a car, we can slow the depletion of our stem cell pool and possibly reverse aging by creating an internal environment that activates SIRT1. Take a look at this new, exciting study:

NAD-dependent histone deacetylase, SIRT1, plays essential roles in the maintenance of hematopoietic stem cells.

Matsui K, Ezoe S, Oritani K, Shibata M, Tokunaga M, McBurney MW, et al.

Hematology and Oncology Dept, Osaka Univ. Grad. Sch. of Medicine, Suita, Japan.

Biochemical and biophysical research communications. 2012 Feb 24;418(4):811-7.

These results suggest that SIRT1 suppresses differentiation of hematopoietic stem/progenitor cells and contributes to the maintenance of stem cell pool.

hematopoietic – pertaining to the formation of blood or blood cells;

progenitor cells – Stem cells differentiate into progenitor cells, which are more developmentally committed to a cell line

PMID: 22306819.


Accolades to David Sinclair’s lab for its great 2004 study that prophetically described the importance of SIRT in this context:

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase.

Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, Howitz KT, Gorospe M, de Cabo R, Sinclair DA.

Pathology Dept, Harvard Med. Sch. 77 Ave.Louis Pasteur, Boston, MA 02115, USA.

Science. 2004 Jul 16;305(5682):390-2. Epub 2004 Jun 17.

A major cause of aging is thought to result from the cumulative effects of cell loss over time… Thus, CR could extend life-span by inducing SIRT1 expression and promoting the long-term survival of irreplaceable cells.

PMID: 15205477.


Our immediate question when we first learned about SIRT1’s importance was “How do we activate it?” It has become overwhelmingly clear that keeping calorie and glucose levels low is best. This makes the protocols in The CR Way to Great Glucose Control even more important to understand and follow.

Leave a Reply

Your email address will not be published. Required fields are marked *

* :

* :

* :