Hormones, aging, disease risk, and calorie restriction

Hormones, aging, disease risk, and calorie restrictionMost of us want to extend life healthfully for as long as possible. If, beyond calorie restriction alone, ways emerge that will help in that process, we are all ears. Dr. Andrzej Bartke, the Featured Guest on the next CR Way Expert Series teleconference , is the person to ask about that. His research has shown that slowing growth without restricting calories can extend the life of mice significantly. He has also shown that long-lived growth-hormone-receptor-knockout mice extend their lives even further when they follow a calorie-restricted diet.

What can we learn from this? How can we apply key learnings from Andy Bartke’s studies to our lives? This will be the focus of the discussion at the expert teleconference next Wednesday evening at 7:30.

Anyone who is considering hormone therapy should make participation in this teleconference a priority. Take a look at this paper for example:

The critical role of metabolic pathways in aging.

Diabetes. 2012 Jun;61(6):1315-22.

Barzilai N, Huffman DM, Muzumdar RH, Bartke A.

Dept. of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA

Abstract

Aging is characterized by a deterioration in the maintenance of homeostatic processes over time, leading to functional decline and increased risk for disease and death. The aging process is characterized metabolically by insulin resistance, changes in body composition, and physiological declines in growth hormone (GH), insulin-like growth factor-1 (IGF-1), and sex steroids. Some interventions designed to address features of aging, such as caloric restriction or visceral fat depletion, have succeeded in improving insulin action and life span in rodents

Meanwhile, pharmacologic interventions and hormonal perturbations have increased the life span of several mammalian species without necessarily addressing features of age-related metabolic decline. These interventions include inhibition of the mammalian target of rapamycin [mTOR] and lifetime deficiency in GH/IGF-1 [Growth Hormone/Insulinlike Growth Factor-1] signaling.

However, strategies to treat aging in humans, such as hormone replacement, have mostly failed to achieve their desired response. We will briefly discuss recent advances in our understanding of the complex role of metabolic pathways in the aging process and highlight important paradoxes that have emerged from these discoveries. Although life span has been the major outcome of interest in the laboratory, a special focus is made in this study on healthspan, as improved quality of life is the goal when translated to humans.

PMID:22618766. NIH, NLM, PubMed access to MEDLINE

 

Here is more of Dr. Bartke’s extraordinary work. Take a look at the studies and send in questions before the teleconference so we can forward them to Dr. Bartke.

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