SIRT 3 Regulates Ketone Production

Have you read about the relationship between the SIRT3 gene and longevity? It is the only sirtuin gene, which has been linked to increased lifespan. It becomes active when energy levels (calories/glucose) are low. Thanks to Dr. Eric Verdin and his insightful colleagues, we now know it regulates ketone production.

Here is the abstract:

SIRT3 Deacetylates Mitochondrial 3-Hydroxy-3-Methylglutaryl CoA Synthase 2 and Regulates Ketone Body Production.

Shimazu T, Hirschey MD, Hua L, Dittenhafer-Reed KE, Schwer B, Lombard
DB, Li Y, Bunkenborg J, Alt FW, Denu JM, Jacobson MP, Verdin E.

Cell Metab. 2010 Dec 1;12(6):654-61.

The mitochondrial sirtuin SIRT3 regulates metabolic homeostasis during fasting and calorie restriction.


Mice lacking
SIRT3 show decreased β-hydroxybutyrate levels during fasting.
Our findings show SIRT3 regulates ketone body production during fasting and provide molecular insight into how protein acetylation can regulate enzymatic activity.

Copyright © 2010 Elsevier Inc. All rights reserved.

PMID: 2110919

This study is important because activating healthy ketone production is associated with increased, cognitive capability –the reason we feature Dr. Verdin at tomorrow’s Brain Booster teleconference and follow logically with Mark Mattson in January. Dr. Mattson made history with a 2003 study that found that time away from food, which activated ketone production, was beneficial to brain health

To help members healthfully activate ketones, we created the CR Way Daily Intermittent Fasting Meal Plan, available in the Getting Smarter section and accessible to full members.

The Getting Smarter forumis free and accessible to everyone and contains quite of information about ketogenesis and healthy ways to activate it.

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