We are pleased to announce that Dr. Joel Schuman, a distinguished scientist, teacher, inventor, and medical doctor – will collaborate with the CR Way DNA HACR research project. Dr. Schuman will be featured on a LivingTheCRWay Expert Teleconference on Monday, November 10 at 7:30 pm (ET)
Dr. Schuman is one of the inventors of optical coherence tomography (OCT) technology, which the project is using in part to evaluate rate of aging, eye health, and the risk of Alzheimer’s disease other dementias.
Get to know Dr. Schuman through this interview on Good Morning America:
Dr. Schuman was also a collaborating scientist on many studies that inspired the use of OCT to evaluate rate of aging.
Considered to be a breakthrough in glaucoma treatment, one of Dr. Schuman’s signature studies is relevant to biochemistry that the CR Way lifestyle deactivates.
Activation of a tissue-specific stress response in the aqueous outflow pathway of the eye defines the glaucoma disease phenotype.
Nature Medicine. 2001 Mar;7(3):304-9.
Wang N, Chintala SK, Fini ME, Schuman JS.
Abstract
The glaucomas are a group of optic neuropathies, comprising the leading cause of irreversible blindness worldwide. Elevated intraocular pressure due to a reduction in normal aqueous outflow is a major causal risk factor.
We found that Endothelial Leukocyte Adhesion Molecule-1 (ELAM-1), the earliest marker for the atherosclerotic plaque in the vasculature, was consistently present on Trabecular Meshwork* (TM) Cells in the outflow pathways of eyes with glaucomas of diverse etiology.
We determined expression of ELAM-1 to be controlled by activation of an interleukin-1 (IL-1) autocrine feedback loop through transcription factor NF-kappaB, and activity of this signaling pathway was shown to protect TM cells against oxidative stress. These findings characterize a protective stress response specific to the eye’s aqueous outflow pathways and provide the first known diagnostic indicator of glaucomatous TM cells.
They further indicate that common mechanisms contribute to the pathophysiology of the glaucomas and vascular diseases.
PMID: 11231628
*The Trabecular Meshwork is eye tissue located around the base of the cornea, near the ciliary body (the structure in the eye that releases a transparent liquid called the aqueous humor). The trabecular meshwork drains the aqueous humor.
The LivingTheCRWay lifestyle reduces NF-kB activity. You may remember that the regulatory gene, SIRT1, activated by a low- calorie and low-GI lifestyle, interacts with NF-kB, lowering inflammatory responses. See: Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase.
Dr. Schuman is the Eye and Ear Foundation Professor and Chairman of Ophthalmology at the University of Pittsburgh. He is also a Professor of Bioengineering and of Clinical and Translational Science and a Professor at the Center for the Neural Basis of Cognition, a University of Pittsburgh/Carnegie Mellon University collaboration. Read more about Dr. Schuman’s distinguished background here.
LivingTheCRWay memberships support the research with Dr. Schuman and other scientists. Find out more.
After hearing Dr. Schuman’s teleconference about OCT retinal assessments and rate of aging, we hope you will be inspired to get an OCT test from your local eye center or to visit the New York area where the Somers Eye Center offers OCT and other important tests for minimal cost.
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